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The plague disease is transmitted by contact-household method when the skins of infected rodents (or camel carcasses) are removed and processed. The food method also has a place to be - for example, you can get sick with the plague when you eat foods that are infected with plague bacteria. Infection with plague by airborne droplets occurs through contact with a sick person with the pneumonic form of plague. The bacterium penetrates through a wound on the human skin, mucous membranes.

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Redness or a sore may form at the site of the pathogen. Through the lymphatic vessels, the bacillus infects the nearest lymph node, which quickly enlarges and becomes inflamed, and there it begins to multiply. The entry of a microorganism into the general bloodstream leads to its spread throughout the body, which provides severe intoxication.

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Cities were enslaved by panic. An interesting example of how the disease was somewhat controlled is the administrative measures taken in Venice. A special sanitary commission was organized there. All ships that sailed were subjected to a special inspection and, if corpses or infected were found, they were burned. Goods and travelers were quarantined for 40 days. The corpses of the dead were immediately collected and buried in a separate lagoon at a depth of at least 1.5 meters.